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Dr David Joffe PhD FRACP's avatar

Yep....

"Everything after COVID is COVID"

- Clinical perspective 🙏🏻🙏🏻

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Glorfindel's avatar

Hi Dr. Leonardi...

Can you post sometime on exactly what an "exhausted T-cell" is?

This term has really got my knickers in a bunch.

Is the 'exhausted T-cell' the product of a chronic infection?

Can a reinfection provoke a T-cell response, but this reinfection generates a population of 'exhausted T-cells' resulting in a less than ideal immune response?

Is the 'exhausted T-cell' completely ineffective or partially effective?

Can the generation of 'exhausted T-cells' lead to pathology?

If you have a reference such as "Exhausted T-Cells for Dummies", that would be helpful.

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