Excellent article. Thanks as always. I will speculate a little here. If T cell activation is essentially the same in those with long COVID and those who recover from infection, perhaps the vascular endothelial cell and nerve cell damage is not too different. Also, megakaryocytes, the precursors of platelets play a role in immune function, and from what I understand once infected, contribute to increased clotting. Increased vascular, nerve cell damage and prothrombotic state. Hmmm, wonder if that contributes to the sudden strokes, heart attacks, deaths and kidney liver and other organ damage in those ASSUMED to have recovered completely from a COVID infection?? Just pure rank speculation, you understand, Dr. Leonardi.:))
Would love to get your take on the issue of IgG4 antibodies after infection or vaccination and how it might be a factor to consider when deciding about timing of taking a booster vaccine. Some are saying (TACT) to be careful about getting a vaccine (or infection -of course) less than 7 months after a previous vaccination. Reason being is that IgG1 and IgG3 antibodies wane early but IgG4 antibodies are being found to increase significantly if someone is vaccinated 2 times within 3-6months. And if the IgG4 population crosses an undefined line in percentage to IgG1 there may be an increase risk of autoimmune disease. Hope I have explained this accurately and hope that you might take the time to do a post on this issue.
Excellent article. Thanks as always. I will speculate a little here. If T cell activation is essentially the same in those with long COVID and those who recover from infection, perhaps the vascular endothelial cell and nerve cell damage is not too different. Also, megakaryocytes, the precursors of platelets play a role in immune function, and from what I understand once infected, contribute to increased clotting. Increased vascular, nerve cell damage and prothrombotic state. Hmmm, wonder if that contributes to the sudden strokes, heart attacks, deaths and kidney liver and other organ damage in those ASSUMED to have recovered completely from a COVID infection?? Just pure rank speculation, you understand, Dr. Leonardi.:))
Sensei...
Glad you have returned to us...timely to say the least as the gates of hell appear to be opening again.
Would love to get your take on the issue of IgG4 antibodies after infection or vaccination and how it might be a factor to consider when deciding about timing of taking a booster vaccine. Some are saying (TACT) to be careful about getting a vaccine (or infection -of course) less than 7 months after a previous vaccination. Reason being is that IgG1 and IgG3 antibodies wane early but IgG4 antibodies are being found to increase significantly if someone is vaccinated 2 times within 3-6months. And if the IgG4 population crosses an undefined line in percentage to IgG1 there may be an increase risk of autoimmune disease. Hope I have explained this accurately and hope that you might take the time to do a post on this issue.